A Nosocomial Outbreak of Diarrhea Caused by Toxin A-negative, Toxin B-positive Clostridium difficile in A Cancer Center Hospital
نویسندگان
چکیده
منابع مشابه
An outbreak of toxin A negative, toxin B positive Clostridium difficile-associated diarrhea in a Canadian tertiary-care hospital.
Toxigenic Clostridium difficile is a frequent cause of infectious nosocomial diarrhea accounting for up to 25% of nosocomial diarrhea cases. Clinically significant disease is thought to be due almost exclusively to C. difficile strains that produce both toxin A and toxin B. Toxigenic C. difficile produces a broad spectrum of gastrointestinal disease varying from asymptomatic carriage to fulmina...
متن کاملGenetic characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates by PCR.
Toxin-specific enzyme immunoassays, cytotoxicity assays, and PCR were used to analyze 48 toxin A-negative, toxin B-positive Clostridium difficile isolates from various geographical sites around the world. All the isolates were negative by the TOX-A TEST and positive by the TOX A/B TEST. A deletion of approximately 1.7 kb was found at the 3' end of the toxA gene for all the isolates, similar to ...
متن کاملEmergence and control of fluoroquinolone-resistant, toxin A-negative, toxin B-positive Clostridium difficile.
BACKGROUND Clostridium difficile is a major cause of infectious diarrhea in hospitalized patients. Between August 2003 and January 2004, we experienced an increase in the incidence of C. difficile-associated disease. We describe the investigation into and management of the outbreak in this article. METHODS A total of 73 consecutive patients with nosocomial C. difficile-associated diarrhea wer...
متن کاملDeletions in the repeating sequences of the toxin A gene of toxin A-negative, toxin B-positive Clostridium difficile strains.
The repeating sequences of the toxin A gene from toxin A-negative, toxin B-positive (toxin A-, toxin B+) strains of Clostridium difficile which were isolated in geographically separated facilities in Japan and Indonesia were determined. All six strains tested had identical repeating sequences with two deletions (1548 and 273 nucleotides in size) in the toxin A gene. A PCR method was designed to...
متن کاملClostridium difficile Infection Caused by Binary Toxin–Positive Strains
To the Editor: With interest, we read the article by Bacci et al. in which they conclude that Clostridium difficile strains containing the binary toxin gene were associated with a higher case-fatality rate after 30 days, even when the analysis was stratified for PCR ribotype (1). Although this was an appealing conclusion, in our opinion the study was severely limited by selection bias and confo...
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ژورنال
عنوان ژورنال: Journal of the Japanese Association for Infectious Diseases
سال: 2004
ISSN: 1884-569X,0387-5911
DOI: 10.11150/kansenshogakuzasshi1970.78.312